药物研发


药物研发应用文献

Gilson是全球制备高效液相色谱领导者,提供一系列的色谱仪器以满足的当今科学家对制备的需求。从适合重排列实验的耐用仪器到使用一次性吸嘴或样品针适合复杂分析实验的仪器,Gilson总能为您提供满足液处理应用需求的自动化解决方案。

 

通过PLC2250结合快速色谱和制备HPLC技术纯化香草醛

 

关键词: Vanillin, Vanilla Extract, PLC Purification Systems, FLASH Chromatography, Preparative HPLC.


通过自动化HPLC系统纯化可用于分析的寡核苷酸的改良制备方法

 

关键词: Oligonucleotides, qPCR, Next Generation Sequencing, Microarray Analysis, GX-271, Purification, TRILUTION LC


通过Gilson LC/MS双功能系统自动制备和再进样分析小分子药物丙磺舒


 

关键词: High-Performance Liquid  Chromatography (HPLC), Mass Spectrometry (MS), Preparative HPLC/MS, Fraction Collection, Fraction Reinjection, Probenecid, TRILUTION LC, Conditional Logic Fraction Collection

 


使用蒸发光散射检测评估含酮萜烯化合物


 

关键词: PrepELS™II Detector, Evaporative Light Scattering (ELS), High-Performance Liquid Chromatography (HPLC), Terpenes, Ketones, Thujone, Camphor, Essential Oil Constituents, Volatile Compounds

 


使用Gilson PIPETMAX® 268将Promega GoTaq® PCR Core System II工作流程自动化


 

关键词: Promega GoTaq PCR Core System II, PIPETMAX 268, Plasmid DNA

 


使用Gilson HPLC系统对剪切后的λ噬菌体基因进行高精度纯化


 

关键词: High-Performance Liquid Chromatography (HPLC), DNA Shearing, DNA Separation, Methylation, Lambda Phage, Gradient Pattern, Electrophoresis, Next-Generataion Sequencing (NGS)

 


使用Gilson GX-281条形码匹配系统自动准备病人样品并进行条形码追踪


 

关键词: GX-281 Liquid Handler, Sample Tracking, Barcode Matching, Laboratory Information Management System (LIMS), Laboratory Informatics, Sample Preparation, Automation, Clinical Laboratory, Patient Samples

 


使用Gilson PLC 2020系统进行连续梯度进样比较不同的pH值条件提取的大豆球蛋白回收率和纯度


 

关键词: Glycinin, Soy Protein, Beta Conglycinin, PLC 2020 Personal Purification System, Semi-Preparative Purification, Extraction, HPLC, Continuous Injection, Large Volume Loading, Automated Loading Pump, Gradient

 


使用Gilson PLC 2020 纯化色谱纯化阿里亚尼考葡萄天然产物


 

关键词: Aglain, Natural Product HPLC Purification, Synthesis, PLC 2020

 


使用Gilson PLC 2020 纯化色谱分离合成的Pleiomaltinine


 

关键词: Pleomaltinine, Synthetic HPLC Purification, PLC 2020, Biologically Active, Pyrone

 


为实验室选择合适的移液工具以优化PCR和qPCR实验


             

关键词: PCR, qPCR, Pipetting, Biomolecule, Disposable Tips, Accuracy, PIPETMAN M, MICROMAN, PIPETMAN L, GmCLab

 


使用聚合物类固相萃取柱富集并通过LC-MS/MS检测饮用水中的农药残留


 

关键词: SPE, Pesticide, Herbicide, Fungicide, Pharmaceuticals, Drinking Water, WHO, National Standards

 


使用固相萃取净化和LC-MS/MS方法测定人血浆中的四氢大麻酚


 

关键词: SPE, Tetrahydrocannabinol, Metabolites, Human Plasma, LC-MS/MS, LC-MS, GC-MS, MS

 


通过固相萃取筛选尿液中甲基苯丙胺和安非他命毒品


 

关键词: SPE, Urine Analysis, Drug Screening, mAMP, AMP

 


通过选择性样品切割和柱切换方法优化对映体的手性分离和纯化


             

关键词: Enantiomers, Purification, Chiral Pharmaceuticals, GX-271 Semi-Preparative HPLC System, Column Switching, Sample Slicing, Sample Cleanup

 


天然产物纯化:从姜科提取生物活性肉桂醛作为美白剂成分


 

关键词: Cosmetics, Natural Products, Zingiberaceae, trans-Cinnamaldehyde, GX-281 Preparative Purification System, Biologically Active Compounds, High Pressure Liquid Chromatography (HPLC)

 


使用手动制备系统纯化高浓度核糖核酸酶A蛋白质


             

关键词: Ribonuclease A (RNAse), Protein, Manual HPLC Purification, Bovine Pancreas, Ion Exchange, High Loading Purification

 


使用Gilson PLC 2020纯化色谱系统纯化蛋白样品


             

关键词: Protein, Anion Exchange, Purification, Gilson PLC 2020

 


使用Gilson GX-271 LC/MS制备色谱系统纯化B-乳球蛋白


 

关键词: B-Lactoglobulin, Protein, Mass-Based Purification, Target Ions, Gilson LC/MS System

 


使用手动HPLC系统扩大制备六聚体合成肽


 

关键词: Peptide, Scale-Up Purification, Gilson Manual System

 


使用自动化LC/MS制备色谱系统纯化合成肽


 

关键词: Peptide, Mass-Based Purification, Target Ions, Gilson LC/MS System

 


使用PLC2020纯化色谱系统纯化25长度单位的ssDNA寡核苷酸


 

关键词: Single Stranded DNA, Oligonucleotides, Purification, Gilson PLC 2020

 


选择合适的实验室仪器:使用Gilson PIPETMAN® M多道移液器、PIPETMAN®L移液器、GX-271 ASPEC®和GX-241进液样工作站完成考马斯蓝蛋白测定

关键词: PIPETMAN® L, PIPETMAN M Multichannel, GX-241 Liquid Handler, GX-274 ASPEC®, Coomassie (Bradford) Protein Assay, Molecular Biology, Automation, Laboratory Equipment

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本科实验方法开发:色谱法课程中所取得的经验

关键词: PLC 2020, Purification, Preparative Chromatography, Reversed Phase Chromatography, Method Development, Sparation Science, Pharmaceuticals

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手动快速自动化制备N-Glycan样品- 零误差样品跟踪和精确移液带来可靠的结果

关键词: N-Glycan, Glycobiology, hlgG, Sample Cleanup, Purification, Glycoanalysis, Microchromatography

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使用Gilson半微量2D液相色谱系统的纯化和分析海洋酵母的生物活性提取物

关键词: 2D HPLC (2 Dimensional High Pressure Liquid Chromatography), TRILUTION LC Liquid Chromatography Software, Gilson 233XL, Bioactive, Marine Yeast

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自动分离用于初步高通量筛选的天然产物粗提取物

 

关键词: Gilson 215 Liquid Chromatography System, TRILUTION LC Liquid Chromatography Software, High Throughput Screening, Natural Products

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使用Gilson PLC 2020纯化色谱系统运行快速色谱法和高压正相色谱法净化天然产物纯化番茄红素和β-胡萝卜素

关键词: PLC 2020, Natural Product Purification, Flash Chromatography, Lycopene, Tea, B-Carotene, Tomatoes

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快速研究——使用Gilson PLC 2020运行正相色谱和快速色谱的对比

关键词: Purification, Normal Phase Chromatography, Flash Chromatography, PLC 2020, Preparative Chromatography

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通过GX-281双Z臂称重系统提升实验室样品自动准备的效率和灵活度

关键词: Weighing Station, GX-281 Liquid Handler, Sample Preparation, Automated Systems, Bar Coding, Tube Gripper, TRILUTION LH v3.0 Liquid Handling Software

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使用Gilson GX-274 ASPEC®全自动固相萃取系统将尿液中苯二氮卓类的固相萃取法自动化

关键词: Gilson GX-274 ASPEC®, TRILUTION® LH, Solid Phase Extraction (SPE), LC/MS-MS Analysis,Diazepam, Benzodiazepines, Urine, Pharmaceuticals

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使用Gilson PLC2020优化纯化梯度的实用手册

关键词: Purification, Pharmaceuticals, Optimal Solvent Gradients, Isolation Gradients, Organic Compounds, PLC 2020, Preparative Chromatography

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使用Gilson  Gilson GX-274和Gilson ASPEC™ XL自动检测尿样中的 VMA, HVA和5-HIAA

关键词: Gilson GX-274, TRILUTION® LH, Catecholamines, Urine, Vanillylmandelic acid (VMA), Homovanilic Acid (HVA), 5-hydroxyindoleacetic Acid (5-HIAA), Tumors, Diagnosis, Biosyntheses, Recipe

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使用Gilson GX-281制备色谱系统从红毛丹壳废物中快速分离Geraniin

关键词: Gilson GX-281 Preparative HPLC System, TRILUTION® LC, Geraniin, Alpha Glucosidase, Alpha Amylase, Aldol Reductase, AGE, Nephelium Lappaceum L., University of Malaysia, Anti-Hyperglycemic Agent, Hyperglycemia, Purification, Natural Products, HPLC, Diabetes

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对质谱和紫外信号采用条件逻辑收集命令从复杂混合物中识别并收集低紫外吸收和含量的兴趣化合物

关键词: Gilson GX-271 LC/MS Purification System, Fraction Collection, Active Pharmaceutical Ingredient (API), Metoprolol, Verapamil, Chloramphenicol, Doxepin, Sulfamethazine

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使用多功能紧凑型台式半制备HPLC系统优化标准手性化合物的纯化方法

关键词: Chiral, Enantiomer, HPLC, Normal Phase Chromatography, PLC 2020 Personal Chromatography System, Preparative Chromatography, Purification, Resolution, Trans-Stilbene Oxide

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使用自动固相萃取法提取化妆品和皮肤药品中的尿囊素并进行HPLC分析

关键词: Allantoin, Automation, CHROMABOND HR-XA, Cosmetics Glyoxylic Acid Diureide, GX-271 ASPEC, HILIC, HPLC, Ointments, Pharmaceuticals, Sample Preparation, Sold Phase Extraction, SPE, Topical Pharmaceuticals, 5-Ureidohydantoin

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对人血清进行快速可重现的处理并对N-聚糖进行质谱分析

关键词: Automation, Biomarkers, Glycans, Glycomics, GX-274 ASPEC, Human Serum, Mass Profiling, Mass Spectrometry, MALDI-FTICR, MS, N-Glycan, N-linked Glycans, Serum, Solid Phase Extraction, SPE

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FTLC 馏分捕获色谱技术

关键词: HPLC, Preparative Chromotography, Gilson FT-LC System

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使用馏分收集系统提升固相萃取方法的回收率并优化精确度

关键词: Solid Phase Extraction, SPE, Serum, Plasma, Urine

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一种使用GX-281半制备色谱系统梯度分离天然产物的全新方法

关键词: GX-281 Purification System, TRILUTION LC, natural compounds, Oregano, Rosmarinic Acid, Carvacol, isolation gradient, purification, fraction collection

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不同溶剂,进样技术和样品量对制备色谱柱的系统影响研究

关键词: Various Solvents, Injection Techniques, Solvents

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cLC:一套完整兼容正相和反相体系的分析和制备色谱解决方案

关键词: Analytical Purification Determination, cLC  System, Reverse-Phase (RP) Chromatography, Normal Phase (NP) Chromatography

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一套可进行少量蛋白结晶工作的自动化液样工作站

关键词: Protein Crystallization, Microbatch

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一套可收集具备/不具备紫外可见光吸收的多功能制备色谱系统

关键词: Active and Non-Active UV/VIS Compounds, ELSD

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使用全自动固相萃取法提取并分析血浆中的氯丙嗪和甲硫哒嗪成分

关键词: Neuroleptic Drugs, SPE, SPE 215

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Fast PCLC:一种适合实验室级的宽泛制备分离应用技术

关键词: Fast PCLC

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使用自动固相萃取从血浆中提取并分析布洛芬和酮基布洛芬成分

关键词: SPE, Ketoprofen, Ibuprofen, Prostaglandin

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麻黄的故事:一种使用自动固相萃取技术从食品和膳食补剂中分析和检测麻黄和麻黄样化合物的方法

关键词: Ephedra, Norephedrine, Pseudoephedrine, Methylephedrine, Dietary Supplements, Nutraceuticals, Gilson SPE 215

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使用弹簧样品针制备MALDI-TOP样品基板

关键词: 223 Sample Changer, Matrix Assisted Laser Desorption/Ionization (MALDI), peptide, MALDI-TOF MS, bradykinin, angiotensin II, ACTH, a-cyano-4-hydroxycinnamic acid, Bruker AnchorChip

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